All energy sources rely on natural resources to make them go. Nuclear relies on actinides. Coal, oil and gas rely on their respective fossil fuels. Wind relies on wind, solar on sunlight, geothermal on subsurface heat. This means that the economics of each power source is dependent upon these inputs to a large degree. If fossil fuels are expensive in a particular area, the fossil fuel economics will be comparatively poor. If availability of wind or sunlight is poor, then ditto for those energy sources.
Nuclear is like fossil fuels in that it depends on a market commodity, whose price can vary. However, unlike fossil fuels, it is not vulnerable overall to that price because the requirement for fuel is only a small fraction of the overall cost. Like renewables, nuclear is mostly capital intensive, with most of the money going into building the power station in the first place. However, despite this, nuclear avoids the pitfalls of renewables of being dependent upon the quality of natural goods in the area.
It looks like nuclear is relatively independent of either critical factor for other energy sources. Does this mean that nuclear economics should be the least variable of all energy economics?